Folate (categories)
Folate range (<45.3 vs >=45.3)
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
33.6502151
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
0.0759394
|
1
|
0.8
|
ns
|
|
Study
|
0.5650209
|
1
|
0.5
|
ns
|
|
GA_samp
|
20.0130767
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
0.0676829
|
1
|
0.8
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
5.342630
|
1
|
0.02
|
*
|
|
Folate_gp
|
2.298542
|
1
|
0.1
|
ns
|
|
Study
|
2.161174
|
1
|
0.1
|
ns
|
|
GA_samp
|
317.190802
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
1.573336
|
1
|
0.2
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
29.5105258
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
0.5252367
|
1
|
0.5
|
ns
|
|
Study
|
0.4103290
|
1
|
0.5
|
ns
|
|
GA_samp
|
94.1392050
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
0.1495187
|
1
|
0.7
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
5.245
|
5.245
|
0.02
|
*
|
|
3
|
Study
|
1
|
Inf
|
3.750
|
3.750
|
0.05
|
ns
|
|
4
|
GA_samp
|
1
|
Inf
|
0.920
|
0.920
|
0.3
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
0.015
|
0.015
|
0.9
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
6.900
|
6.900
|
0.009
|
**
|
|
3
|
Study
|
1
|
Inf
|
7.383
|
7.383
|
0.007
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.449
|
0.449
|
0.5
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
0.116
|
0.116
|
0.7
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
8.911
|
8.911
|
0.003
|
**
|
|
3
|
Study
|
1
|
Inf
|
27.555
|
27.555
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.478
|
0.478
|
0.5
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
2.501
|
2.501
|
0.1
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
15.44 (6.19, 38.40)
|
<0.0001
|
|
Folate_gp≥45.3
|
1.01 (0.82, 1.24)
|
0.93
|
|
StudySTOP
|
1.12 (0.82, 1.55)
|
0.48
|
|
GA_samp
|
1.13 (1.07, 1.20)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.74 (1.04, 2.87)
|
0.03
|
|
Folate_gp≥45.3
|
0.94 (0.83, 1.07)
|
0.37
|
|
StudySTOP
|
1.20 (1.00, 1.44)
|
0.05
|
|
GA_samp
|
1.33 (1.29, 1.38)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.16 (0.09, 0.32)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.92 (0.78, 1.09)
|
0.33
|
|
StudySTOP
|
0.93 (0.73, 1.20)
|
0.59
|
|
GA_samp
|
1.22 (1.17, 1.27)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
18.50 (4.95, 69.20)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.75 (0.57, 0.97)
|
0.03
|
|
StudySTOP
|
0.65 (0.41, 1.04)
|
0.07
|
|
GA_samp
|
1.04 (0.96, 1.13)
|
0.34
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.72 (1.39, 23.54)
|
0.02
|
|
Folate_gp≥45.3
|
0.70 (0.53, 0.93)
|
0.01
|
|
StudySTOP
|
0.52 (0.32, 0.85)
|
0.009
|
|
GA_samp
|
1.03 (0.94, 1.13)
|
0.50
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
6.89 (5.31, 8.95)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.90 (0.85, 0.96)
|
0.002
|
|
StudySTOP
|
0.79 (0.73, 0.85)
|
<0.0001
|
|
GA_samp
|
0.99 (0.97, 1.01)
|
0.51
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
72.05286
|
15.20468
|
56.19899
|
47.21477
|
109.9574
|
|
STOP
|
80.95288
|
13.51384
|
24.25452
|
57.37005
|
114.2298
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
60.17924
|
4.912917
|
121.14938
|
51.19825
|
70.73564
|
|
STOP
|
72.16384
|
3.267865
|
41.06058
|
65.85731
|
79.07429
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
1.835249
|
0.2048767
|
142.13560
|
1.471824
|
2.288412
|
|
STOP
|
1.714043
|
0.0983096
|
52.70028
|
1.527755
|
1.923047
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
26.11216
|
5.075430
|
Inf
|
17.83998
|
38.22004
|
|
STOP
|
17.05872
|
1.464529
|
Inf
|
14.41680
|
20.18477
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
6.954116
|
1.443253
|
Inf
|
4.630033
|
10.444791
|
|
STOP
|
3.609646
|
0.333788
|
Inf
|
3.011293
|
4.326893
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.960279
|
0.2147877
|
Inf
|
5.553826
|
6.396479
|
|
STOP
|
4.710949
|
0.0946799
|
Inf
|
4.528987
|
4.900222
|
Comparisons (Overall)
|
Hormone
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥45.3 / <45.3
|
1.01 (0.82, 1.25)
|
0.9
|
|
hPL (μg/ml)
|
≥45.3 / <45.3
|
0.94 (0.83, 1.07)
|
0.4
|
|
GH2 (ng/ml)
|
≥45.3 / <45.3
|
0.92 (0.78, 1.09)
|
0.3
|
|
Insulin (uU/ml)
|
≥45.3 / <45.3
|
0.75 (0.57, 0.97)
|
0.03
|
|
HOMA-IR
|
≥45.3 / <45.3
|
0.70 (0.53, 0.93)
|
0.01
|
|
Glucose (mmol/L)
|
≥45.3 / <45.3
|
0.90 (0.85, 0.96)
|
0.002
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
